Lung cancer is a disease in which cancer cells grow in the lungs. The most common type of lung cancer include:
- Non-small cell lung cancer—generally grows and spreads more slowly (most common)
- Small cell lung cancer—generally grows more quickly and is more likely to spread to other parts of the body
Lung cancer is the leading cause of cancer deaths in the US for both men and women.
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Cancer occurs when cells in the body divide without control or order. Normally, cells divide in a regulated manner. If cells keep dividing uncontrollably when new cells are not needed, a mass of tissue forms, called a growth or tumor. The term cancer refers to malignant growths. These growths can invade nearby tissues. Cancer that has invaded nearby tissues can then spread to other parts of the body.
The following can cause damage to the cells in the lungs, leading to lung cancer:
- First- or second-hand smoke from cigarettes, cigars, or pipes
- Exposure to asbestos (a type of mineral) or radon (radioactive gas)
Factors that may increase your chances of lung cancer:
- Using chewing tobacco
- Exposure to second-hand smoke
- Exposure to to asbestos or radon
- Having a lung disease, such as tuberculosis
- Family or personal history of lung cancer
- Exposure to to certain air pollutants
- Exposure to to coal dust
- Radiation therapy that was used to treat other cancers
- HIV infection
The doctor will ask about your symptoms and medical history. A physical exam will be done. The doctor will also ask about:
- Smoking history
- Substances that you have been exposed to
- Family history of cancer
Tests may include:
- Sputum cytology—a test that examines of a sample of mucus from the lungs
- Biopsy—removal of a sample of lung tissue to be examined under a microscope
Imaging tests evaluate the lungs and other structures. These may include:
- Chest x-ray
- Spiral CT
- PET scan
- PET/CT scan
- Bone scan
The physical exam combined with all of your test results, will help to determine the stage of cancer you have. Staging is used to guide your treatment plan. Like other cancers, lung cancer is staged from I-IV. Stage I is a very localized cancer, while stage IV indicates a spread to other parts of the body.
The goal of treatment is to eliminate the cancer and/or control the symptoms.
Surgery involves removing the tumor and nearby tissue. Lymph nodes may also need to be removed. The type of surgery depends on the location of the tumor such as:
- Segmental or wedge resection—removal of only a small part of the lung
- Lobectomy —removal of an entire lobe of the lung
- Pneumonectomy—removal of an entire lung
Radiation therapy is the use of radiation to kill cancer cells and shrink tumors. This may also be used to relieve symptoms such as shortness of breath. External radiation is usually used to treat lung cancer. With this treatment, radiation is directed at the tumor from a source outside of the body.
Chemotherapy is the use of drugs to kill cancer cells. This may be given in many forms, including pill, injection, and via a catheter. Chemotherapy is often used to kill lung cancer cells that have spread to other parts of the body.
Researchers continue to study ways to treat lung cancer. The National Cancer Institute considers these potential therapies:
- Photodynamic therapy (PDT)—A type of laser therapy. A chemical is injected into the bloodstream. It is then absorbed by the cells of the body. The chemical rapidly leaves normal cells. It will remain in cancer cells for a longer time. A laser aimed at the cancer activates the chemical. This chemical then kills the cancer cells that have absorbed it. This treatment may also be used to reduce symptoms.
- Cryosurgery—A treatment that freezes and destroys cancer tissue.
Other treatments that are being researched include:
- Targeted therapy—involves using medications or substances to target certain molecules in the cancer cells
- Immunotherapy—involves using medications or substances made by the body to increase or restore the body's natural defenses against cancer
To help reduce your chances of lung cancer:
- Do not start smoking. If you smoke, talk to your doctor about how to successfully quit.
- Avoid places where people are smoking.
- Test your home for radon gases and asbestos. Have these substances removed if they are in the home.
- Try to avoid or limit occupational exposures.
The American Lung Association and American Cancer Society both suggest that screening for lung cancer with a low-dose CT scan may be considered if you are a smoker (or former smoker), aged 55-74 years, and have a history of heavy smoking (such as one pack a day for 30 years).
This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.
Edits to original content made by Denver Health.
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a (NSCLC; Non-small Cell Lung Cancer; Non-small Cell Bronchogenic Carcinoma; Small Cell Lung Cancer)
American Cancer Society https://www.cancer.org
American Lung Association http://www.lung.org
Canadian Cancer Society http://www.cancer.ca
The Lung Association https://www.lung.ca
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Small cell lung cancer. EBSCO DynaMed Plus website. Available at: http://www.dynamed.com/topics/dmp~AN~T115654/Small-cell-lung-cancer . Updated June 23, 2017. Accessed October 9, 2017.
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