A pituitary adenoma is a growth, or tumor, in the pituitary gland. The pituitary is a small gland at the base of the brain. It makes hormones that affect growth and the action of other glands in the body.
Pituitary adenomas are usually not cancer and will not spread to other parts of the body. However, they can lead to vision and growth problems. A pituitary adenoma can also change the balance of hormones of the thyroid, adrenal, and gonad glands.
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DNA changes cause the growth of a tumor. It is not always clear what causes these changes.
Some tumors are part of other endocrine disorders. These disorder may be caused by genes that are passed down in families. Tumors may also be caused by exposure to cancer-causing substances or radiation.
Symptoms can vary. They will depend on the size of the tumor and if the tumor is sending out hormones. The tumor can also cause problem because it is at the base of the brain. Some may not have any symptoms.
Symptoms due to size may include:
- Blurred vision or tunnel vision
A prolactin-secreting adenoma may cause:
- Milk production in nonlactating women
- Loss of or irregular periods
- Lack of interest in sex
- Vaginal dryness
A thyrotropin-secreting adenoma may cause swelling of the neck.
If the adenoma causes hyperthyroidism it may lead to:
- Rapid heartbeat
- Weight loss
A corticotropin-secreting adenoma may cause:
- Menstrual disturbance
- Skin changes such as increased facial hair in women, acne, bruising, or bluish stretch marks
- Buffalo hump, an increase in fatty tissue on the back
- Obesity, especially around the wrist
- Round face
A growth hormone-secreting adenoma may cause:
- Enlarged hands and feet
- Excessive growth and height
- Oily skin
- Excess sweating
Pituitary adenomas may also play a role in:
- Kidney stones
- Cardiovascular disease
- High blood pressure
Treatment will depend on the size and impact of the tumor. Tumor that are not causing problems may not need immediate treatment. The doctor will schedule regular exams to track any changes.
Treatment may focus on managing hormone changes caused by the tumor or tumor removal. Several treatment may be used in combination. Treatment choices may include:
Tumors that are pressing on nearby structures may need to be removed. Many may be removed through the nose. Healthy pituitary gland tissue may also be removed during surgery. Hormone medicine may be needed after surgery.
Medicine can control symptoms and sometimes shrink the tumor. They can also block hormones from the tumor.
Medicine may be useful for prolactin or growth hormone-secreting adenomas.
Radiation therapy can kill tumor cells. The types of radiation therapy used to treat pituitary adenomas include:
- Conventional therapy—radiation is directed at the pituitary from a source outside the body
- Stereotactic radiosurgery—an intense radiation beam is targeted directly at the tumor
- Proton beam radiotherapy—a beam of protons is focused on the tumor
This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.
Edits to original content made by Denver Health.
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a (Pituitary Tumor; Nervous System Tumor)
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