Rheumatoid Arthritis



Rheumatoid arthritis (RA) is a disorder of the joints. It causes pain, swelling, stiffness, and loss of function in the joints.

Rheumatoid Arthritis
rheumatoid arthritis
© Nucleus Medical Media, Inc.


RA is caused by a problem with the immune system. It begins to attack healthy tissue. It is not clear what makes this happen. It is most likely a combination of factors in a person's genes and environment. Some causes may be:

  • Genes—people with RA often have a specific genetic defect
  • Defects in the immune system—may stop the immune cells from recognizing the body’s own tissues
  • Infection with specific viruses or bacteria—may start an abnormal immune response
  • Chemical or hormonal imbalances in the body

Risk Factors

RA is more common in women. It often starts in people who are between 30 to 60 years of age.

Other things that may raise the risk are:

  • Having other family members with RA
  • Heavy or long term smoking



Pain and swelling usually happens in smaller joints, such as the hands, wrists, and feet. It also affects joints on the same side of the body.

Other problems may be:

  • Pain, stiffness, and swelling in the morning and after inactivity that lasts more than 30 minutes
  • Red, warm joints
  • Deformed, misshapen joints
  • Lack of energy
  • Weight loss
  • Muscle aches
  • Small lumps or nodules under the skin


You will be asked about your symptoms and health history. A physical exam will be done. There are many diseases that have symptoms that are similar to RA. Tests will be done to rule out other health problems.

Blood tests may be done to look for inflammation and blood proteins linked to RA.

Pictures may be taken to look for tissue swelling and changes in bone. This can be done with:

  • X-rays
  • Ultrasound
  • MRI scan

Samples may be taken of fluid and tissues to look for signs of RA. This can be done with:

  • Arthrocentesis —fluid from the joint
  • Synovial biopsy—a piece of the lining of the joint



There is no cure for RA. The goal of treatment is to:

  • Slow damage
  • Ease pain and swelling
  • Improve function

Choices are:

  • Supportive care, such as rest and splints
  • Lifestyle changes, such as exercise, counseling, and support groups
  • Medicines to ease pain and swelling, such as:
    • Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen and COX-2 inhibitors
    • Disease-modifying antirheumatic drugs (DMARDs that suppress or enhance the immune system
    • Corticosteroids (less common)

Some people may need surgery if there is severe damage or loss of function. Options are replacing a joint or repairing a tendon.


There are no guidelines to prevent RA.

This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.

Edits to original content made by Denver Health.

a (RA; Arthritis, Rheumatoid)


American College of Rheumatology http://www.rheumatology.org 

Arthritis Foundation http://www.arthritis.org 


The Arthritis Society http://arthritis.ca 

Canadian Rheumatology Association http://rheum.ca 


Aletaha D, Smolen JS. Diagnosis and Management of Rheumatoid Arthritis: A Review. JAMA. 2018 Oct 2;320(13);1360-1372.

Rheumatoid arthritis. Arthritis Foundation website. Available at: http://www.arthritis.org/about-arthritis/types/rheumatoid-arthritis. Accessed October 9, 2020.

Rheumatoid arthritis. Merck Manual Professional Version website. Available at: http://www.merckmanuals.com/professional/musculoskeletal-and-connective-tissue-disorders/joint-disorders/rheumatoid-arthritis-ra. Accessed October 9, 2020.

Rheumatoid arthritis. National Institute of Arthritis and Musculoskeletal and Skin Diseases website. Available at: http://www.niams.nih.gov/Health%5FInfo/Rheumatic%5FDisease/default.asp. Accessed October 9, 2020.

Rheumatoid arthritis (RA). EBSCO DynaMed website. Available at:  https://www.dynamed.com/condition/rheumatoid-arthritis-ra  . Accessed October 9, 2020.

Singh JA, Saag KG, et al. 2015 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis. Arthritis Rheumatol. 2016;68(1):1-26.