Inflammation is a normal part of how the body acts toward an infection or injury. However, the inflammation should pass once the area has healed. With sarcoidosis the inflammation does not pass. The cells that cause the inflammation stay and cause granulomas. It is not clear why this happens. An infection or exposure to a toxin in the environment may trigger the change.
Sarcoidosis is more common in females and at ages 20 to 40 years old. Factors that may increase the chance of sarcoidosis include:
- Ethnic descent—African-American, Northern European, Scandinavian, and Irish
- History of sarcoidosis in:
- Parents and siblings
- Uncle, aunt, nephew, niece, grandparent, grandchild, and half-sibling
- Exposures to dusty or moldy environment or certain occupations
There are few symptoms in early stages. Symptoms will depend on what organs are affected. Symptoms may come and go.
Many will feel flu-like symptoms such as:
- Swollen lymph nodes
Lungs are often affected and can cause:
- Shortness of breath
- Chest pain
- Fatigue, especially with exertion
- Night sweats
Other possible symptoms may include:
- Rash with swelling—erythema nodosum
- Pain or irritation of eyes
- Muscle weakness
- Loss of appetite
- Weight loss
- Difficulty hearing
- Blurred vision or blindness—if the eye is affected
- Poor coordination
- Trouble walking
- Irregular heart rate
- Pain, swelling, and stiffness in the joints
- Facial paralysis known as Bell's palsy
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The doctor will ask about your symptoms and medical history. A physical exam will be done including listening to the heart and lungs and checking lymph nodes. Tests that may help find sarcoidosis signs or rule out other causes include:
- Chest x-rays—can show sarcoidosis spots in the lungs or swollen lymph nodes
- Biopsy—to look for granulomas or signs of other conditions such as infections
There is no specific test that confirms sarcoidosis. Instead, diagnosis is based on:
- Combination of typical symptoms and results of imaging tests (mainly x-ray)
- Biopsy that shows granulomas - may be from any organ
- Eliminating other causes of illness
Other tests may be done to see how well the affected organs are working. Tests may be done even if there are no symptoms and may include:
- Blood tests—to check liver health
- Urine tests—to check kidney health
- Electrocardiogram (EKG)—to test heart health
- Pulmonary function tests (PFTs)—to test lung health
Not all sarcoidosis needs to be treated. Many will only have minor symptoms and the sarcoidosis will pass on its own. The doctor will monitor for any changes including regular eye exams and lung tests.
Treatment may be needed to ease more serious symptoms. It can also help to decrease the chance of permanent problems. Treatment may include:
Medication may help to manage the inflammation and decrease damage. Options include:
- Steroids to decrease inflammation
- Topical steroids to treat rashes
- Methotrexate, azathioprine, or anti-tumor necrosis factor biologics for those who do not respond to steroids
- Nonsteroidal anti-inflammatory drugs (NSAIDs) to treat musculoskeletal symptoms
- Eye drops to treat mild eye problems
- Antimicrobial drugs (antimalarial drugs or tetracyclines) to treat mild skin involvement
Pulmonary rehabilitation may help to improve lung function.
If function does not improve or other treatments have failed, organ transplants may be needed. This may include the heart, lung, liver, or kidneys.
This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.
Edits to original content made by Denver Health.
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American Lung Association http://www.lung.org
Arthritis Foundation http://www.arthritis.org
The Arthritis Society http://www.arthritis.ca
The Lung Association http://www.lung.ca
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