The exact cause is not known. It may be due to genetics, the environment, or a problem with how the immune system works.

Risk Factors

This health problem is more common in women. It often starts between 20 and 50 years of age.

The risk of this problem is raised in people who have other family members with lupus.



Symptoms differ from person to person and by type of scleroderma.

A person with the localized type may have:

  • Patches of thick, hard skin that are oval in shape
  • Lines of thickened skin on the arms, legs, or face

A person with the systemic type may have:

  • Numbness, discomfort, or a change in skin color in the fingers and toes
  • Tight, thickened, or shiny skin
  • Muscle pain
  • Diarrhea or problems passing stool
Raynaud Phenomenon Symptom
Low blood flwo to fingers, vasoconstriction
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The doctor will ask about your symptoms and health history. A physical exam will be done.

These tests may also be done:

  • Blood tests to look for antibodies linked to scleroderma
  • A skin biopsy

Images may be taken of structures in your body. This can be done with:

  • X-ray
  • CT scan
  • MRI scan
  • Echocardiogram



There is no cure. The goal of treatment is to manage the symptoms a person is having. Choices are:

  • Medicines to:
    • Ease pain and swelling
    • Treat skin changes
    • Widen blood vessels
    • Suppress the immune system
    • Reduce stomach acid
  • Physical therapy to help with strength and flexibility
  • Occupational therapy to learn how to do day-to-day activities
  • Phototherapy to thin out the skin


There are no known guidelines to prevent this health problem.

This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.

Edits to original content made by Denver Health.