Diabetic Neuropathy



Diabetic neuropathy is likely caused by a combination of factors, including:

  • Metabolic factors such as elevated blood pressure, high blood glucose, longer duration of diabetes, high cholesterol, and possibly low levels of insulin
  • Damage to blood vessels going to nerves
  • Autoimmune factors causing inflammation of nerves
  • Nerve trauma
  • Genetics
  • Smoking or alcohol abuse

Risk Factors

This condition is more common in older adults.

Factors that may increase your risk of diabetic neuropathy include:

  • Having diabetes for 25 years or more
  • Having type 2 diabetes
  • High blood pressure
  • Obesity
  • Lack of exercise
  • Peripheral artery disease (PAD)
  • High cholesterol



Symptoms of diabetic neuropathy may include:

  • Numbness, tingling, or pain in the extremities
  • Weakness in the arms and/or legs
  • Indigestion
  • Nausea or vomiting
  • Diarrhea or constipation
  • Lightheadedness
  • Urination problems
  • Erectile dysfunction or vaginal dryness
  • Weakness of facial muscles resulting in a drooping eyelid, drooping mouth, facial droop, difficulty swallowing
  • Muscle cramps
  • A prolonged feeling of fullness after eating, and/or abdominal pain
  • Decreased ability to sweat normally
  • Blurred or double vision

If you have diabetic neuropathy, you are at increased risk for developing other types of neuropathies, such as carpal tunnel syndrome .

Diabetic neuropathy can lead to serious complications, including foot ulcers , infection, and limb loss.


You will be asked about your symptoms and medical history. A physical exam will be done. A foot exam will also be done.

Your nerve function may be tested, especially if you have muscle weakness. This can be done with:

  • Nerve conduction studies
  • Electromyography
  • Quantitative sensory testing—the use of stimuli to check for neuropathy
  • Quantitative sudomotor axon reflex test—a test to evaluate the nerve supply of sweat glands

Images may be taken of your bodily structures. This can be done with an ultrasound .

Your nerves may need to be tested. This can be done with a biopsy .



Treatment may include:

Blood Glucose Management

It is important to regularly monitor blood glucose levels. Meal planning, exercise, and/or medications can help.

Foot Care

Footcare will be needed to avoid ulcers . The nerves in the feet are the ones most often affected by neuropathy. This care will involve regular visits to a foot doctor and careful cleaning, inspection, moisturizing, and grooming of the feet. In addition, always wear well-fitting shoes and thick, soft, seamless socks to help protect your feet from injuries.


Nerve decompression surgery may be done to reduce pain.

Other Treatments

Other treatments will depend on symptoms.

  • Medications can be used to relieve pain, burning, tingling, or numbness from peripheral neuropathy .
    • Often, the medications used to treat these symptoms are the same ones used to treat seizures and depression .
    • Another option to treat pain is called transcutaneous electrical nerve stimulation (TENS). With TENS, a machine sends painless electrical signals through the skin to the nerves.
    • Other options include relaxation training, biofeedback, yoga, massage, acupuncture
  • Medications and treatment may also be needed to control symptoms from autonomic neuropathy, such as gastrointestinal, heart, or urinary problems


The best way to prevent diabetic neuropathy is to regularly monitor and manage your blood glucose levels. Your doctor can instruct you about how often to check your levels and what the numbers mean.

This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.

Edits to original content made by Denver Health.