Gastrointestinal Stromal Tumor
Gastrointestinal stromal tumors (GISTs) are a type of tumor found in the digestive system. This includes the esophagus, liver, stomach, gallbladder, large and small intestines, rectum, and anus. The digestive organs break down food. The body uses the nutrients and gets rid of the waste. About half of GISTs happen in the stomach. But, they can they can happen anywhere in this system.
GISTs are rare. They are considered as potentially cancerous.
|GIST may occur anywhere in the digestive system.|
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GISTs may not cause any symptoms until they grow to a certain size. If you have them, GISTs may cause:
- Tiredness and weakness
- Fever or sweating at night
- Weight loss
- Feeling full after eating a small amount of food
- Belly pain
- Painless lump in the belly
- Nausea or vomiting
- Blood in stool or vomit
- Problems swallowing
Your doctor will ask about your symptoms and health history. Your answers and a physical exam may point to a GIST.
You may have:
- Abdominal CT scan
- MRI scan
- Fine-needle biopsy —a tissue sample is taken and checked in a lab
- Tests on your genes
- PET scan
The exam and your test results will help find out the stage of the tumors. Staging guides your treatment. GISTs are staged from 1-4. Stage 1 is very localized. Stage 4 is a spread to other parts of the body.
Treatment will depend on the stage. More than one method may be used:
- Surgery—Used to treat a GIST that has not spread. The chances of cancer spreading are higher if the GIST sac is opened during surgery. Some or all of the tumor may be removed. This depends on the size and if it's growing. Doing so lowers the chance of it growing enough to block how the digestive system works.
- Medicines—Used to shrink the tumor or stop it from growing. They may be given before surgery.
This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.
Edits to original content made by Denver Health.
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a (GIST; Gastrointestinal Stromal Sarcoma; Gastric Myosarcoma; Gastric Myoblastoma; Gastrointestinal Leiomyosarcoma; Gastrointestinal Smooth Muscle Tumor)
American Cancer Society https://www.cancer.org
American College of Gastroenterology http://patients.gi.org
Canadian Association of Gastroenterology https://www.cag-acg.org
Canadian Cancer Society https://www.cancer.ca
Basu S, Balaji S, Bennett DH, Davies N. Gastrointestional stromal tumors (GIST) and laparoscopic resection. Surg Endosc. 2007;21(10):1685-1689.
Demetri GD, von Mehren M, Blanke CD, et al. Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Engl J Med. 2002;347(7):472-480.
Duffaud F, Blay J. Gastrointestinal stromal tumors: biology and treatment. Oncology. 2003;65(3):187-197.
Gastrointestinal stromal tumor. Ped Surg Update. 2005;24(6):3.
Gastrointestinal stromal tumor (GIST) American Cancer Society website. Available at: http://www.cancer.org/cancer/gastrointestinalstromaltumorgist/detailedguide/gastrointestinal-stromal-tumor-what-is-gist. Accessed August 15, 2018.
Gastrointestinal stromal tumor (GIST). EBSCO DynaMed Plus website. Available at: http://www.dynamed.com/topics/dmp~AN~T219072/Gastrointestinal-stromal-tumor-GIST . Updated January 8, 2018. Accessed August 15, 2018.
Gastrointestinal stromal tumors (GISTs). Macmillan Cancer Support website. Available at: https://www.macmillan.org.uk/information-and-support/soft-tissue-sarcomas/gastrointestinal-stromal-tumours. Accessed August 15, 2018.
Huang HY, Li CF, Huang WW, et al. A modification of NIH consensus criteria to better distinguish the highly lethal subset of primary localized gastrointestinal stromal tumors: A subdivision of the original high-risk group on the basis of outcome. Surgery. 2007;141(6):748
Rubin BP, Heinrich MC, Corless CL. Gastrointestinal stromal tumour. Lancet. 2007;369(9574):1731-1741.
Shinomura Y, Kinoshita K, Tsutsui S, Hirota S. Pathophysiology, diagnosis, and treatment of gastrointestinal stromal tumors. J Gastroenterol. 2005;40(8):775-780.