Trauma Center Research & Publications

Ongoing research is a vital component of Denver Health's Rocky Mountain Regional Level I Trauma Center and allows Denver Health to provide the most advanced and highest quality trauma care to patients.

Denver Health’s trauma surgeons, in conjunction with colleagues from the University of Colorado School of Medicine, are continually researching predictors of multiple organ failure in critically injured trauma patients and subsequent outcomes.

Members of the trauma team are involved in numerous research studies including those involving blood substitutes, the use of bicycle helmets, emergency response times, alcohol use and others. This research helps Denver Health achieve some of the best patient outcomes in Colorado.

Denver Health’s trauma surgeons are internationally published. Ernest E. “Gene” Moore, M.D., was recognized by The Journal of Trauma Injury, Infection, and Critical Care as being the world’s most cited author.

Denver Health’s Surgery and Orthopedic Research Departments recently added a flow cytometer to the laboratory. In one ongoing research study, it is being used to analyze changes in the surface antigens of the neutrophil following orthopedic trauma.

Trauma Critical Research Unit

Denver Health's Surgery and Trauma Critical Research unit specializes in conducting studies involving the prevention and management of the consequences of trauma in all its phases and environments. This includes: transportation from the scene of injury, the Emergency Department, the Operating Room, the Post-Anesthesia Care Unit and Surgical Intensive Care Unit, and subsequent inpatient and outpatient hospital care.

In this setting, indications for prophylactic or therapeutic intervention with investigational products (whether pharmaceutical, biologic or device) include but are not limited to: hemorrhagic shock, septic shock, hypothermia, anemia, hemostasis, ischemia, analgesia, inflammation, infection, healing (bone/wound), clotting disorders, post-operative bowel dysfunction and organ failure.

Patients undergoing and/or recovering from emergent and elective surgery are routinely considered for inclusion in relevant clinical trials.

Close cooperation between the Paramedic Division, Emergency Medicine, Anesthesiology and Surgery Departments ensures successful research collaboration.

Grant Funding

The Trauma Surgeons at Denver Health have been funded by the National Institutes of Health since 1988 to investigate the pathogenesis and develop therapy to prevent Postinjury Adult Respiratory Distress Syndrome and Multiple Organ Failure. In collaboration with Dr. Alden Harken at UCHSC, they are sponsored as a Program Center entitled "Trauma Prime Cells." The trauma surgeons at Denver Health have also conducted FDA Phase I, II and III studies with a blood substitute entitled "PolyHeme." Collectively, the Department of Surgery at Denver Health publishes more than 50 peer-reviewed manuscripts annually.



Validation of the age-adjusted shock index using pediatric trauma quality improvement program data

Nordin A, Coleman A, Shi J, Wheeler K, Xiang H, Acker S, Bensard D, Kenney B.

J Pediatr Surg. 2017 Oct 12. pii: S0022-3468(17)30645-0. doi: 10.1016/j.jpedsurg.2017.10.023. [Epub ahead of print]

Rapid Response Team Activations in Pediatric Surgical Patients

Acker SN, Wathen B, Roosevelt GE, Hill LR, Schubert A, Reese J, Bensard DD, Kulungowski AM.

Eur J Pediatr Surg. 2017 Feb;27(1):81-85. doi: 10.1055/s-0036-1593384. Epub 2016 Oct 5.

Shock index, pediatric age-adjusted (SIPA) is more accurate than age-adjusted hypotension for trauma team activation

Acker SN, Bredbeck B, Partrick DA, Kulungowski AM, Barnett CC, Bensard DD.

Surgery. 2017 Mar;161(3):803-807. doi: 10.1016/j.surg.2016.08.050. Epub 2016 Nov 1.

Adult-Based Massive Transfusion Protocol Activation Criteria Do Not Work in Children

Acker SN, Hall B, Hill L, Partrick DA, Bensard DD.

Eur J Pediatr Surg. 2017 Feb;27(1):32-35. doi: 10.1055/s-0036-1587587. Epub 2016 Aug 17.

Early Definitive Fracture Fixation is Safely Performed in the Presence of an Open Abdomen in Multiply Injured Patients

Glass NE, Burlew CC, Hahnhaussen J, Weckbach S, Pieracci FM, Moore EE, Stahel PF.

J Orthop Trauma. 2017 Dec;31(12):624-630. doi: 10.1097/BOT.0000000000000959.

Cervical spine evaluation and clearance in the intoxicated patient: A prospective Western Trauma Association Multi-Institutional Trial and Survey

Martin MJ, Bush LD, Inaba K, Byerly S, Schreiber M, Peck KA, Barmparas G, Menaker J, Hazelton JP, Coimbra R, Zielinski MD, Brown CVR, Ball CG, Cherry-Bukowiec JR, Burlew CC, Dunn J, Minshall CT, Carrick MM, Berg GM, Demetriades D, Long W; WTA C-Spine Study Group.

J Trauma Acute Care Surg. 2017 Dec;83(6):1032-1040. doi: 10.1097/TA.0000000000001650.

Discussion of: "Targeting resuscitation to normalization of coagulating status: Hyper and hypocoagulability after severe injury are both associated with increased mortality"

Moore HB, Moore EE, Liras IN, Wade C, Huebner BR, Burlew CC, Pieracci FM, Sauaia A, Cotton BA.

Am J Surg. 2017 Dec;214(6):1046-1047. doi: 10.1016/j.amjsurg.2017.10.013. Epub 2017 Oct 5. No abstract available.

Natural history of splenic vascular abnormalities after blunt injury: A Western Trauma Association multicenter trial

Zarzaur BL, Dunn JA, Leininger B, Lauerman M, Shanmuganathan K, Kaups K, Zamary K, Hartwell JL, Bhakta A, Myers J, Gordy S, Todd SR, Claridge JA, Teicher E, Sperry J, Privette A, Allawi A, Burlew CC, Maung AA, Davis KA, Cogbill T, Bonne S, Livingston DH, Coimbra R, Kozar RA.

J Trauma Acute Care Surg. 2017 Dec;83(6):999-1005. doi: 10.1097/TA.0000000000001597.

Preperitoneal pelvic packing is effective for hemorrhage control in open pelvic fractures

Moskowitz EE, Burlew CC, Moore EE, Pieracci FM, Fox CJ, Campion EM, Lawless RA, Cohen MJ.

Am J Surg. 2017 Nov 22. pii: S0002-9610(17)30772-9. doi: 10.1016/j.amjsurg.2017.11.024. [Epub ahead of print]

Fat emboli syndrome and the orthopaedic trauma surgeon: lessons learned and clinical recommendations

Dunn RH, Jackson T, Burlew CC, Pieracci FM, Fox C, Cohen M, Campion EM, Lawless R, Mauffrey C.

Int Orthop. 2017 Sep;41(9):1729-1734. doi: 10.1007/s00264-017-3507-1. Epub 2017 May 30.

Preperitoneal pelvic packing for exsanguinating pelvic fractures

Burlew CC.

Int Orthop. 2017 Sep;41(9):1825-1829. doi: 10.1007/s00264-017-3485-3. Epub 2017 Apr 26. Review.

2017 update of the WSES guidelines for emergency repair of complicated abdominal wall hernias

Birindelli A, Sartelli M, Di Saverio S, Coccolini F, Ansaloni L, van Ramshorst GH, Campanelli G, Khokha V, Moore EE, Peitzman A, Velmahos G, Moore FA, Leppaniemi A, Burlew CC, Biffl WL, Koike K, Kluger Y, Fraga GP, Ordonez CA, Novello M, Agresta F, Sakakushev B, Gerych I, Wani I, Kelly MD, Gomes CA, Faro MP Jr, Tarasconi A, Demetrashvili Z, Lee JG, Vettoretto N, Guercioni G, Persiani R, Tranà C, Cui Y, Kok KYY, Ghnnam WM, Abbas AE, Sato N, Marwah S, Rangarajan M, Ben-Ishay O, Adesunkanmi ARK, Lohse HAS, Kenig J, Mandalà S, Coimbra R, Bhangu A, Suggett N, Biondi A, Portolani N, Baiocchi G, Kirkpatrick AW, Scibé R, Sugrue M, Chiara O, Catena F.

World J Emerg Surg. 2017 Aug 7;12:37. doi: 10.1186/s13017-017-0149-y. eCollection 2017. Review.

Preperitoneal pelvic packing reduces mortality in patients with life-threatening hemorrhage due to unstable pelvic fractures

Burlew CC, Moore EE, Stahel PF, Geddes AE, Wagenaar AE, Pieracci FM, Fox CJ, Campion EM, Johnson JL, Mauffrey C.

J Trauma Acute Care Surg. 2017 Feb;82(2):233-242. doi: 10.1097/TA.0000000000001324.

Risk Factors for the Development of Acute Respiratory Distress Syndrome Following Hemorrhage

Robinson BRH, Cohen MJ, Holcomb JB, Pritts TA, Gomaa D, Fox EE, Branson RD, Callcut RA, Cotton BA, Schreiber MA, Brasel KJ, Pittet JF, Inaba K, Kerby JD, Scalea TM, Wade CE, Bulger EM; PROPPR Study Group.

Shock. 2017 Nov 30. doi: 10.1097/SHK.0000000000001073. [Epub ahead of print]

Correlation between factor (F)XIa, FIXa and tissue factor and trauma severity

Prior SM, Cohen MJ, Conroy AS, Nelson MF, Kornblith LZ, Howard BM, Butenas S.

J Trauma Acute Care Surg. 2017 Jun;82(6):1073-1079. doi: 10.1097/TA.0000000000001449.

Western Trauma Association Critical Decisions in Trauma: Management of adult blunt splenic trauma-2016 updates

Rowell SE, Biffl WL, Brasel K, Moore EE, Albrecht RA, DeMoya M, Namias N, Schreiber MA, Cohen MJ, Shatz DV, Karmy-Jones R, Moore FA.

J Trauma Acute Care Surg. 2017 Apr;82(4):787-793. doi: 10.1097/TA.0000000000001323. No abstract available.

Damage control resuscitation in patients with severe traumatic hemorrhage: A practice management guideline from the Eastern Association for the Surgery of Trauma

Cannon JW, Khan MA, Raja AS, Cohen MJ, Como JJ, Cotton BA, Dubose JJ, Fox EE, Inaba K, Rodriguez CJ, Holcomb JB, Duchesne JC.

J Trauma Acute Care Surg. 2017 Mar;82(3):605-617. doi: 10.1097/TA.0000000000001333.

Targeted clinical control of trauma patient coagulation through a thrombin dynamics model

Menezes AA, Vilardi RF, Arkin AP, Cohen MJ.

Sci Transl Med. 2017 Jan 4;9(371). pii: eaaf5045. doi: 10.1126/scitranslmed.aaf5045.

Individual clotting factor contributions to mortality following trauma

Kunitake RC, Howard BM, Kornblith LZ, Christie SA, Conroy AS, Cohen MJ, Callcut RA.

J Trauma Acute Care Surg. 2017 Feb;82(2):302-308. doi: 10.1097/TA.0000000000001313.

Coagulopathy of Trauma

Cohen MJ, Christie SA.

Crit Care Clin. 2017 Jan;33(1):101-118. doi: 10.1016/j.ccc.2016.08.003. Review.

Contemporary management of subclavian and axillary artery injuries-A Western Trauma Association multicenter review

Waller CJ, Cogbill TH, Kallies KJ, Ramirez LD, Cardenas JM, Todd SR, Chapman KJ, Beckman MA, Sperry JL, Anto VP, Eriksson EA, Leon SM, Anand RJ, Pearlstein M, Capano-Wehrle L, Cothren Burlew C, Fox CJ, Cullinane DC, Roberts JC, Harrison PB, Berg GM, Haan JM, Lightwine K.

J Trauma Acute Care Surg. 2017 Dec;83(6):1023-1031. doi: 10.1097/TA.0000000000001645.

Arteriovenous fistula between the common femoral artery and vein secondary to transpelvic gunshot wound

Asensio JA, Ogun OA, Wagner M, Fox CJ.

J Trauma Acute Care Surg. 2017 Mar;82(3):646-648. doi: 10.1097/TA.0000000000001311. No abstract available.

A negative urinalysis is associated with a low likelihood of intra-abdominal injury after blunt abdominal trauma

Jones TS, Stovall RT, Jones EL, Knepper B, Pieracci FM, Fox CJ, Moore EE, Cothren Burlew C.

Am J Surg. 2017 Jan;213(1):69-72. doi: 10.1016/j.amjsurg.2016.05.005. Epub 2016 Jun 12.

Fibrinolysis shutdown is associated with a fivefold increase in mortality in trauma patients lacking hypersensitivity to tissue plasminogen activator

Moore HB, Moore EE, Huebner BR, Dzieciatkowska M, Stettler GR, Nunns GR, Lawson PJ, Ghasabyan A, Chandler J, Banerjee A, Silliman C, Sauaia A, Hansen KC.

J Trauma Acute Care Surg. 2017 Dec;83(6):1014-1022. doi: 10.1097/TA.0000000000001718.

The Pitfalls of REBOA: Risk Factors and Mitigation Strategies

Davidson AJ, Russo RM, Reva VA, Brenner ML, Moore LJ, Ball C, Bulger E, DuBose JJ, Moore EE, Rasmussen TE; BEST Study Group.

J Trauma Acute Care Surg. 2017 Oct 4. doi: 10.1097/TA.0000000000001711. [Epub ahead of print]

Hemorrhagic shock and tissue injury drive distinct plasma metabolome derangements in swine

Clendenen N, Nunns GR, Moore EE, Reisz JA, Gonzalez E, Peltz E, Silliman CC, Fragoso M, Nemkov T, Wither MJ, Hansen K, Banerjee A, Moore HB, DʼAlessandro A.

J Trauma Acute Care Surg. 2017 Oct;83(4):635-642. doi: 10.1097/TA.0000000000001504.

Use of Uncrossmatched Erythrocytes in Emergency Bleeding Situations

Yazer MH, Waters JH, Spinella PC, Cap CA, Fahie CRL Sr, Gourdine E, Jenkins DH, Kleinman S, Moore EE, Ness P, Shinar E, Sloan SR, Stubbs JR, Ward KR; AABB (formerly known as the American Association of Blood Banks)/Trauma, Hemostasis, Oxygenation Resuscitation Network (THOR) Working Party.

Anesthesiology. 2017 Dec 15. doi: 10.1097/ALN.0000000000002037. [Epub ahead of print] No abstract available.

Current trends in the management of hemodynamically unstable pelvic ring injuries

Stahel PF, Burlew CC, Moore EE.

Curr Opin Crit Care. 2017 Dec;23(6):511-519. doi: 10.1097/MCC.0000000000000454.

Targeting resuscitation to normalization of coagulating status: Hyper and hypocoagulability after severe injury are both associated with increased mortality

Moore HB, Moore EE, Liras IN, Wade C, Huebner BR, Burlew CC, Pieracci FM, Sauaia A, Cotton BA.

Am J Surg. 2017 Dec;214(6):1041-1045. doi: 10.1016/j.amjsurg.2017.08.036. Epub 2017 Sep 18.

Platelet adenosine diphosphate receptor inhibition provides no advantage in predicting need for platelet transfusion or massive transfusion

Stettler GR, Moore EE, Moore HB, Nunns GR, Huebner BR, Einersen P, Ghasabyan A, Silliman CC, Banerjee A, Sauaia A.

Surgery. 2017 Dec;162(6):1286-1294. doi: 10.1016/j.surg.2017.07.022. Epub 2017 Sep 28.

Plasma succinate is a predictor of mortality in critically injured patients

DʼAlessandro A, Moore HB, Moore EE, Reisz JA, Wither MJ, Ghasasbyan A, Chandler J, Silliman CC, Hansen KC, Banerjee A.

J Trauma Acute Care Surg. 2017 Sep;83(3):491-495. doi: 10.1097/TA.0000000000001565.

All animals are equal but some animals are more equal than others: Plasma lactate and succinate in hemorrhagic shock: A comparison in rodents, swine, non-human primates and injured patients

Reisz JA, Wither MJ, Moore EE, Slaughter AL, Moore HB, Ghasabyan A, Chandler J, Schaub LJ, Fragoso M, Nunns G, Silliman CC, Hansen KC, Banerjee A, Sheppard FR, D'alessandro A.

J Trauma Acute Care Surg. 2017 Nov 3. doi: 10.1097/TA.0000000000001721. [Epub ahead of print]

Shootout at the O.K. Corral-History Revisited

Vercruysse GA, Bauman ZM, Roman J, Rhee PM, Moore EE.

J Trauma Acute Care Surg. 2017 Nov;83(5):981-983. doi: 10.1097/TA.0000000000001632. No abstract available.

Splenic trauma: WSES classification and guidelines for adult and pediatric patients

Coccolini F, Montori G, Catena F, Kluger Y, Biffl W, Moore EE, Reva V, Bing C, Bala M, Fugazzola P, Bahouth H, Marzi I, Velmahos G, Ivatury R, Soreide K, Horer T, Ten Broek R, Pereira BM, Fraga GP, Inaba K, Kashuk J, Parry N, Masiakos PT, Mylonas KS, Kirkpatrick A, Abu-Zidan F, Gomes CA, Benatti SV, Naidoo N, Salvetti F, Maccatrozzo S, Agnoletti V, Gamberini E, Solaini L, Costanzo A, Celotti A, Tomasoni M, Khokha V, Arvieux C, Napolitano L, Handolin L, Pisano M, Magnone S, Spain DA, de Moya M, Davis KA, De Angelis N, Leppaniemi A, Ferrada P, Latifi R, Navarro DC, Otomo Y, Coimbra R, Maier RV, Moore F, Rizoli S, Sakakushev B, Galante JM, Chiara O, Cimbanassi S, Mefire AC, Weber D, Ceresoli M, Peitzman AB, Wehlie L, Sartelli M, Di Saverio S, Ansaloni L.

World J Emerg Surg. 2017 Aug 18;12:40. doi: 10.1186/s13017-017-0151-4. eCollection 2017. Review.


Thrombelastography indicates limitations of animal models of trauma-induced coagulopathy

Stettler GR, Moore EE, Moore HB, Lawson PJ, Fragoso M, Nunns GR, Silliman CC, Banerjee A.

J Surg Res. 2017 Sep;217:207-212. doi: 10.1016/j.jss.2017.05.027. Epub 2017 May 11.

The role of open abdomen in non-trauma patient: WSES Consensus Paper

Coccolini F, Montori G, Ceresoli M, Catena F, Moore EE, Ivatury R, Biffl W, Peitzman A, Coimbra R, Rizoli S, Kluger Y, Abu-Zidan FM, Sartelli M, De Moya M, Velmahos G, Fraga GP, Pereira BM, Leppaniemi A, Boermeester MA, Kirkpatrick AW, Maier R, Bala M, Sakakushev B, Khokha V, Malbrain M, Agnoletti V, Martin-Loeches I, Sugrue M, Di Saverio S, Griffiths E, Soreide K, Mazuski JE, May AK, Montravers P, Melotti RM, Pisano M, Salvetti F, Marchesi G, Valetti TM, Scalea T, Chiara O, Kashuk JL, Ansaloni L.

World J Emerg Surg. 2017 Aug 14;12:39. doi: 10.1186/s13017-017-0146-1. eCollection 2017. Review.

Red blood cells in hemorrhagic shock: a critical role for glutaminolysis in fueling alanine transamination in rats

Reisz JA, Slaughter AL, Culp-Hill R, Moore EE, Silliman CC, Fragoso M, Peltz ED, Hansen KC, Banerjee A, D'Alessandro A.

Blood Adv. 2017 Jul 14;1(17):1296-1305. doi: 10.1182/bloodadvances.2017007187. eCollection 2017 Jul 25.

Nonhuman primate model of polytraumatic hemorrhagic shock recapitulates early platelet dysfunction observed following severe injury in humans

Schaub LJ, Moore HB, Cap AP, Glaser JJ, Moore EE, Sheppard FR.

J Trauma Acute Care Surg. 2017 Mar;82(3):461-469. doi: 10.1097/TA.0000000000001343.


History of the Innovation of Damage Control for Management of Trauma Patients: 1902-2016

Roberts DJ, Ball CG, Feliciano DV, Moore EE, Ivatury RR, Lucas CE, Fabian TC, Zygun DA, Kirkpatrick AW, Stelfox HT.

Ann Surg. 2017 May;265(5):1034-1044. doi: 10.1097/SLA.0000000000001803.


Tissue injury suppresses fibrinolysis after hemorrhagic shock in nonhuman primates (rhesus macaque)

Macko AR, Moore HB, Cap AP, Meledeo MA, Moore EE, Sheppard FR.

J Trauma Acute Care Surg. 2017 Apr;82(4):750-757. doi: 10.1097/TA.0000000000001379.


The need for a National Trauma Institute within the National Institutes of Health

Moore HB, Maier RV, Moore EE.

J Trauma Acute Care Surg. 2017 Mar;82(3):649. doi: 10.1097/TA.0000000000001367. No abstract available.


Damage Control Resuscitation

Samuels JM, Moore HB, Moore EE.

Chirurgia (Bucur). 2017 Sept-Oct;112(5):514-523. doi: 10.21614/chirurgia.112.5.514.


Pelvic trauma: WSES classification and guidelines

Coccolini F, Stahel PF, Montori G, Biffl W, Horer TM, Catena F, Kluger Y, Moore EE, Peitzman AB, Ivatury R, Coimbra R, Fraga GP, Pereira B, Rizoli S, Kirkpatrick A, Leppaniemi A, Manfredi R, Magnone S, Chiara O, Solaini L, Ceresoli M, Allievi N, Arvieux C, Velmahos G, Balogh Z, Naidoo N, Weber D, Abu-Zidan F, Sartelli M, Ansaloni L.

World J Emerg Surg. 2017 Jan 18;12:5. doi: 10.1186/s13017-017-0117-6. eCollection 2017. Review.

Management of Trauma-Induced Coagulopathy with Thrombelastography

Gonzalez E, Moore EE, Moore HB.

Crit Care Clin. 2017 Jan;33(1):119-134. doi: 10.1016/j.ccc.2016.09.002. Review.


Rapid thrombelastography thresholds for goal-directed resuscitation of patients at risk for massive transfusion

Einersen PM, Moore EE, Chapman MP, Moore HB, Gonzalez E, Silliman CC, Banerjee A, Sauaia A.

J Trauma Acute Care Surg. 2017 Jan;82(1):114-119. doi: 10.1097/TA.0000000000001270.


Western Trauma Association Critical Decisions in Trauma: Management of rib fractures

Brasel KJ, Moore EE, Albrecht RA, deMoya M, Schreiber M, Karmy-Jones R, Rowell S, Namias N, Cohen M, Shatz DV, Biffl WL.

J Trauma Acute Care Surg. 2017 Jan;82(1):200-203. doi: 10.1097/TA.0000000000001301.


Indications for surgical stabilization of rib fractures in patients without flail chest: surveyed opinions of members of the Chest Wall Injury Society

Pieracci FM, Agarwal S, Doben A, Shiroff A, Lottenberg L, Whitbeck SA, White TW.

Int Orthop. 2018 Feb;42(2):401-408. doi: 10.1007/s00264-017-3612-1. Epub 2017 Aug 29.


Reply to "Open reduction and internal fixation of rib fractures in polytrauma patients with flail chest" by DeFreest et al

Doben AR, Pieracci FM.

Am J Surg. 2017 Jun;213(6):1189. doi: 10.1016/j.amjsurg.2016.07.029. Epub 2016 Aug 28. No abstract available


Chest Wall Trauma

Majercik S, Pieracci FM.

Thorac Surg Clin. 2017 May;27(2):113-121. doi: 10.1016/j.thorsurg.2017.01.004. Review.



Establishing Benchmarks for Resuscitation of Traumatic Circulatory Arrest: Success-to-Rescue and Survival among 1,708 Patients
Moore HB, Moore EE, Burlew CC, Biffl WL, Pieracci FM, Barnett CC, Bensard DD, Jurkovich GJ, Fox CJ, Sauaia A.
J Am Coll Surg. 2016 Jul;223(1):42-50. doi: 10.1016/j.jamcollsurg.2016.04.013. Epub 2016 Apr 21.

Goal-directed Hemostatic Resuscitation of Trauma-induced Coagulopathy: A Pragmatic Randomized Clinical Trial Comparing a Viscoelastic Assay to Conventional Coagulation Assays
Gonzalez E, Moore EE, Moore HB, Chapman MP, Chin TL, Ghasabyan A, Wohlauer MV, Barnett CC, Bensard DD, Biffl WL, Burlew CC, Johnson JL, Pieracci FM, Jurkovich GJ, Banerjee A, Silliman CC, Sauaia A.Ann Surg. 2016 Jun;263(6):1051-9. doi: 10.1097/SLA.0000000000001608.

Pediatric emergency department thoracotomy: A 40-year review

Moore HB, Moore EE, Bensard DD.

J Pediatr Surg. 2016 Feb;51(2):315-8. doi: 10.1016/j.jpedsurg.2015.10.040. Epub 2015 Oct 19.

A paradigm for achieving successful pediatric trauma verification in the absence of pediatric surgical specialists while ensuring quality of care

Falcone RA Jr, Milliken WJ, Bensard DD, Haas L, Daugherty M, Gray L, Tuggle DW, Garcia VF.

J Trauma Acute Care Surg. 2016 Mar;80(3):433-9. doi: 10.1097/TA.0000000000000945.

Expanded screening criteria for blunt cerebrovascular injury: a bigger impact than anticipated

Geddes AE, Burlew CC, Wagenaar AE, Biffl WL, Johnson JL, Pieracci FM, Campion EM, Moore EE.

Am J Surg. 2016 Dec;212(6):1167-1174. doi: 10.1016/j.amjsurg.2016.09.016. Epub 2016 Sep 29.

Cervical spinal clearance: A prospective Western Trauma Association Multi-institutional Trial

Inaba K, Byerly S, Bush LD, Martin MJ, Martin DT, Peck KA, Barmparas G, Bradley MJ, Hazelton JP, Coimbra R, Choudhry AJ, Brown CV, Ball CG, Cherry-Bukowiec JR, Burlew CC, Joseph B, Dunn J, Minshall CT, Carrick MM, Berg GM, Demetriades D; WTA C-Spine Study Group.

J Trauma Acute Care Surg. 2016 Dec;81(6):1122-1130.

RibScore: A novel radiographic score based on fracture pattern that predicts pneumonia, respiratory failure, and tracheostomy

Chapman BC, Herbert B, Rodil M, Salotto J, Stovall RT, Biffl W, Johnson J, Burlew CC, Barnett C, Fox C, Moore EE, Jurkovich GJ, Pieracci FM.

J Trauma Acute Care Surg. 2016 Jan;80(1):95-101. doi: 10.1097/TA.0000000000000867.


Discovering the truth about life after discharge: Long-term trauma-related mortality

Callcut RA, Wakam G, Conroy AS, Kornblith LZ, Howard BM, Campion EM, Nelson MF, Mell MW, Cohen MJ.

J Trauma Acute Care Surg. 2016 Feb;80(2):210-7. doi: 10.1097/TA.0000000000000930.

Delayed presentation of pulmonary hernia following surgical stabilization of severe rib fractures

Ibrahim-Zada I, Bell MT, Campion EM, Pieracci FM, Truitt MS.

J Trauma Acute Care Surg. 2016 Aug;81(2):397-9. doi: 10.1097/TA.0000000000001102. No abstract available.

Reconsidering the Resources Needed for Multiple Casualty Events: Lessons Learned From the Crash of Asiana Airlines Flight 214

Campion EM, Juillard C, Knudson MM, Dicker R, Cohen MJ, Mackersie R, Campbell AR, Callcut RA.

JAMA Surg. 2016 Jun 1;151(6):512-7. doi: 10.1001/jamasurg.2015.5107.

Western Trauma Association Critical Decisions in Trauma: Management of pelvic fracture with hemodynamic instability-2016 updates

Tran TL, Brasel KJ, Karmy-Jones R, Rowell S, Schreiber MA, Shatz DV, Albrecht RM, Cohen MJ, DeMoya MA, Biffl WL, Moore EE, Namias N.

J Trauma Acute Care Surg. 2016 Dec;81(6):1171-1174. No abstract available.

The Impact of Pre-Hospital Administration of Lactated Ringer's Solution versus Normal Saline in Patients with Traumatic Brain Injury

Rowell SE, Fair KA, Barbosa RR, Watters JM, Bulger EM, Holcomb JB, Cohen MJ, Rahbar MH, Fox EE, Schreiber MA.

J Neurotrauma. 2016 Jun 1;33(11):1054-9. doi: 10.1089/neu.2014.3478. Epub 2016 Feb 25.

The acute respiratory distress syndrome following isolated severe traumatic brain injury

Hendrickson CM, Howard BM, Kornblith LZ, Conroy AS, Nelson MF, Zhuo H, Liu KD, Manley GT, Matthay MA, Calfee CS, Cohen MJ.

J Trauma Acute Care Surg. 2016 Jun;80(6):989-97. doi: 10.1097/TA.0000000000000982.

Inducing Acute Traumatic Coagulopathy In Vitro: The Effects of Activated Protein C on Healthy Human Whole Blood

Howard BM, Kornblith LZ, Cheung CK, Kutcher ME, Miyazawa BY, Vilardi RF, Cohen MJ.

PLoS One. 2016 Mar 23;11(3):e0150930. doi: 10.1371/journal.pone.0150930. eCollection 2016.

A novel low-profile ER-REBOA catheter is not fluoroscopy-free

Fox CJ.

J Trauma Acute Care Surg. 2016 Jun;80(6):1053. doi: 10.1097/TA.0000000000001021. No abstract available.

Multicenter evaluation of temporary intravascular shunt use in vascular trauma

Inaba K, Aksoy H, Seamon MJ, Marks JA, Duchesne J, Schroll R, Fox CJ, Pieracci FM, Moore EE, Joseph B, Haider AA, Harvin JA, Lawless RA, Cannon J, Holland SR, Demetriades D; Multicenter Shunt Study Group.

J Trauma Acute Care Surg. 2016 Mar;80(3):359-64; discussion 364-5. doi: 10.1097/TA.0000000000000949.


Control the damage: morbidity and mortality after emergent trauma laparotomy

Harvin JA, Wray CJ, Steward J, Lawless RA, McNutt MK, Love JD, Moore LJ, Wade CE, Cotton BA, Holcomb JB.

Am J Surg. 2016 Jul;212(1):34-9. doi: 10.1016/j.amjsurg.2015.10.014. Epub 2015 Dec 15.

Glutamine metabolism drives succinate accumulation in plasma and the lung during hemorrhagic shock

Slaughter AL, D'Alessandro A, Moore EE, Banerjee A, Silliman CC, Hansen KC, Reisz JA, Fragoso M, Wither MJ, Bacon AW, Moore HB, Peltz ED.

J Trauma Acute Care Surg. 2016 Dec;81(6):1012-1019.

WSES classification and guidelines for liver trauma

Coccolini F, Catena F, Moore EE, Ivatury R, Biffl W, Peitzman A, Coimbra R, Rizoli S, Kluger Y, Abu-Zidan FM, Ceresoli M, Montori G, Sartelli M, Weber D, Fraga G, Naidoo N, Moore FA, Zanini N, Ansaloni L.

World J Emerg Surg. 2016 Oct 10;11:50. eCollection 2016. Review.


Safety of minimizing preoperative starvation in critically ill and intubated trauma patients

Parent BA, Mandell SP, Maier RV, Minei J, Sperry J, Moore EE, O'Keefe GE.

J Trauma Acute Care Surg. 2016 Jun;80(6):957-63. doi: 10.1097/TA.0000000000001011.


Metabolomics of trauma-associated death: shared and fluid-specific features of human plasma vs lymph

D'alessandro A, Nemkov T, Moore HB, Moore EE, Wither M, Nydam T, Slaughter A, Silliman CC, Banerjee A, Hansen KC.

Blood Transfus. 2016 May;14(2):185-94. doi: 10.2450/2016.0208-15. Epub 2016 Apr 22.


WSES Guidelines for the management of acute left sided colonic diverticulitis in the emergency setting

Sartelli M, Catena F, Ansaloni L, Coccolini F, Griffiths EA, Abu-Zidan FM, Di Saverio S, Ulrych J, Kluger Y, Ben-Ishay O, Moore FA, Ivatury RR, Coimbra R, Peitzman AB, Leppaniemi A, Fraga GP, Maier RV, Chiara O, Kashuk J, Sakakushev B, Weber DG, Latifi R, Biffl W, Bala M, Karamarkovic A, Inaba K, Ordonez CA, Hecker A, Augustin G, Demetrashvili Z, Melo RB, Marwah S, Zachariah SK, Shelat VG, McFarlane M, Rems M, Gomes CA, Faro MP, Júnior GA, Negoi I, Cui Y, Sato N, Vereczkei A, Bellanova G, Birindelli A, Di Carlo I, Kok KY, Gachabayov M, Gkiokas G, Bouliaris K, Çolak E, Isik A, Rios-Cruz D, Soto R, Moore EE.

World J Emerg Surg. 2016 Jul 29;11:37. doi: 10.1186/s13017-016-0095-0. eCollection 2016. Review.


Fatality and Severity of Firearm Injuries in a Denver Trauma Center, 2000-2013

Sauaia A, Gonzalez E, Moore HB, Bol K, Moore EE.

JAMA. 2016 Jun 14;315(22):2465-7. doi: 10.1001/jama.2016.5978. No abstract available.


Gunshot wounds: A review of ballistics, bullets, weapons, and myths

Rhee PM, Moore EE, Joseph B, Tang A, Pandit V, Vercruysse G.

J Trauma Acute Care Surg. 2016 Jun;80(6):853-67. doi: 10.1097/TA.0000000000001037. No abstract available.


Indications for Use of Damage Control Surgery in Civilian Trauma Patients: A Content Analysis and Expert Appropriateness Rating Study

Roberts DJ, Bobrovitz N, Zygun DA, Ball CG, Kirkpatrick AW, Faris PD, Brohi K, D'Amours S, Fabian TC, Inaba K, Leppäniemi AK, Moore EE, Navsaria PH, Nicol AJ, Parry N, Stelfox HT.

Ann Surg. 2016 May;263(5):1018-27. doi: 10.1097/SLA.0000000000001347.


Rationale for the selective administration of tranexamic acid to inhibit fibrinolysis in the severely injured patient

Moore EE, Moore HB, Gonzalez E, Sauaia A, Banerjee A, Silliman CC.

Transfusion. 2016 Apr;56 Suppl 2:S110-4. doi: 10.1111/trf.13486.


Acute Fibrinolysis Shutdown after Injury Occurs Frequently and Increases Mortality: A Multicenter Evaluation of 2,540 Severely Injured Patients

Moore HB, Moore EE, Liras IN, Gonzalez E, Harvin JA, Holcomb JB, Sauaia A, Cotton BA.

J Am Coll Surg. 2016 Apr;222(4):347-55. doi: 10.1016/j.jamcollsurg.2016.01.006. Epub 2016 Jan 22.


Validation of the Denver Emergency Department Trauma Organ Failure Score to Predict Post-Injury Multiple Organ Failure

Vogel JA, Newgard CD, Holmes JF, Diercks DB, Arens AM, Boatright DH, Bueso A, Gaona SD, Gee KZ, Nelson A, Voros JJ, Moore EE, Colwell CB, Haukoos JS; Western Emergency Services Translational Research Network.

J Am Coll Surg. 2016 Jan;222(1):73-82. doi: 10.1016/j.jamcollsurg.2015.10.010. Epub 2015 Oct 24.


Overwhelming tPA release, not PAI-1 degradation, is responsible for hyperfibrinolysis in severely injured trauma patients

Chapman MP, Moore EE, Moore HB, Gonzalez E, Gamboni F, Chandler JG, Mitra S, Ghasabyan A, Chin TL, Sauaia A, Banerjee A, Silliman CC.

J Trauma Acute Care Surg. 2016 Jan;80(1):16-23; discussion 23-5. doi: 10.1097/TA.0000000000000885.


A prospective, controlled clinical evaluation of surgical stabilization of severe rib fractures

Pieracci FM, Lin Y, Rodil M, Synder M, Herbert B, Tran DK, Stoval RT, Johnson JL, Biffl WL, Barnett CC, Cothren-Burlew C, Fox C, Jurkovich GJ, Moore EE.

J Trauma Acute Care Surg. 2016 Feb;80(2):187-94. doi: 10.1097/TA.0000000000000925.



Lack of utility of repeat monitoring of hemoglobin and hematocrit following blunt solid organ injury in children

Acker SN, Petrun B, Partrick DA, Roosevelt GE, Bensard DD.

J Trauma Acute Care Surg. 2015 Dec;79(6):991-4; discussion 994. doi: 10.1097/TA.0000000000000791.

A pediatric specific shock index in combination with GMS identifies children with life threatening or severe traumatic brain injury

Acker SN, Ross JT, Partrick DA, Bensard DD.

Pediatr Surg Int. 2015 Nov;31(11):1041-6. doi: 10.1007/s00383-015-3789-6. Epub 2015 Sep 9.

Early diffuse slowing on electroencephalogram in pediatric traumatic brain injury: Impact on management and prognosis

Nadlonek NA, Acker SN, Bensard DD, Bansal S, Partrick DA.

J Pediatr Surg. 2015 Aug;50(8):1338-40. doi: 10.1016/j.jpedsurg.2015.03.060. Epub 2015 Apr 9.

When is it safe to forgo abdominal CT in blunt-injured children?

Acker SN, Stewart CL, Roosevelt GE, Partrick DA, Moore EE, Bensard DD.

Surgery. 2015 Aug;158(2):408-12. doi: 10.1016/j.surg.2015.03.037. Epub 2015 May 18.

Beyond morbidity and mortality: the social and legal outcomes of non-accidental trauma

Acker SN, Roach JP, Partrick DA, Karrer FM, Bensard DD, Sirotnak AP.

J Pediatr Surg. 2015 Apr;50(4):604-7. doi: 10.1016/j.jpedsurg.2014.05.030. Epub 2014 Jul 11.

Pediatric specific shock index accurately identifies severely injured children

Acker SN, Ross JT, Partrick DA, Tong S, Bensard DD.

J Pediatr Surg. 2015 Feb;50(2):331-4. doi: 10.1016/j.jpedsurg.2014.08.009. Epub 2014 Oct 1.

The found down patient: A Western Trauma Association multicenter study

Howard BM, Kornblith LZ, Conroy AS, Burlew CC, Wagenaar AE, Chouliaras K, Hill JR, Carrick MM, Mallory GR, Watkins JR, Truitt MS, Ciesla DJ, Davis JA, Vail CJ, Kemp Bohan PM, Nelson MF, Callcut RA, Cohen MJ; Western Trauma Association Multicenter Study Group.

J Trauma Acute Care Surg. 2015 Dec;79(6):976-82; discussion 982. doi: 10.1097/TA.0000000000000862.

Analysis of Total Human Urinary Glycosaminoglycan Disaccharides by Liquid Chromatography-Tandem Mass Spectrometry

Sun X, Li L, Overdier KH, Ammons LA, Douglas IS, Burlew CC, Zhang F, Schmidt EP, Chi L, Linhardt RJ.

Anal Chem. 2015 Jun 16;87(12):6220-7. doi: 10.1021/acs.analchem.5b00913. Epub 2015 Jun 2.

Trauma, Time, and Transfusions: A Longitudinal Analysis of Coagulation Markers in Severely Injured Trauma Patients Receiving Modified Whole Blood or Component Blood Products

Rahbar E, Cardenas JC, Matijevic N, Del Junco D, Podbielski J, Cohen MJ, Cotton BA, Holcomb JB, Wade CE; Early Whole Blood Investigators.

Shock. 2015 Nov;44(5):417-25. doi: 10.1097/SHK.0000000000000449.

Clinical assessment of trauma-induced coagulopathy and its contribution to postinjury mortality: A TACTIC proposal

Neal MD, Moore HB, Moore EE, Freeman K, Cohen MJ, Sperry JL, Zuckerbraun BS, Park MS; TACTIC Investigators.

J Trauma Acute Care Surg. 2015 Sep;79(3):490-2. doi: 10.1097/TA.0000000000000793. No abstract available.

Statistical Machines for Trauma Hospital Outcomes Research: Application to the PRospective, Observational, Multi-Center Major Trauma Transfusion (PROMMTT) Study

Moore SE, Decker A, Hubbard A, Callcut RA, Fox EE, Del Junco DJ, Holcomb JB, Rahbar MH, Wade CE, Schreiber MA, Alarcon LH, Brasel KJ, Bulger EM, Cotton BA, Muskat P, Myers JG, Phelan HA, Cohen MJ; PROMMTT Study Group.

PLoS One. 2015 Aug 21;10(8):e0136438. doi: 10.1371/journal.pone.0136438. eCollection 2015.

Beyond emergency surgery: redefining acute care surgery

Privette AR, Evans AE, Moyer JC, Nelson MF, Knudson MM, Mackersie RC, Callcut RA, Cohen MJ.

J Surg Res. 2015 Jun 1;196(1):166-71. doi: 10.1016/j.jss.2014.11.012. Epub 2014 Nov 14.

Pretrauma center red blood cell transfusion is associated with reduced mortality and coagulopathy in severely injured patients with blunt trauma

Brown JB, Cohen MJ, Minei JP, Maier RV, West MA, Billiar TR, Peitzman AB, Moore EE, Cuschieri J, Sperry JL; Inflammation and the Host Response to Injury Investigators.

Ann Surg. 2015 May;261(5):997-1005. doi: 10.1097/SLA.0000000000000674.

Re: REBOA and catheter-based technology in trauma

Biffl WL, Fox CJ, Moore EE.

J Trauma Acute Care Surg. 2015 Jul;79(1):175. doi: 10.1097/TA.0000000000000702. No abstract available.

The role of REBOA in the control of exsanguinating torso hemorrhage

Biffl WL, Fox CJ, Moore EE.

J Trauma Acute Care Surg. 2015 May;78(5):1054-8. doi: 10.1097/TA.0000000000000609. Review.

Western Trauma Association Critical Decisions in Trauma: Diagnosis and management of esophageal injuries

Biffl WL, Moore EE, Feliciano DV, Albrecht RA, Croce M, Karmy-Jones R, Namias N, Rowell S, Schreiber M, Shatz DV, Brasel K.

J Trauma Acute Care Surg. 2015 Dec;79(6):1089-95. doi: 10.1097/TA.0000000000000772.


Indications for use of thoracic, abdominal, pelvic, and vascular damage control interventions in trauma patients: A content analysis and expert appropriateness rating study

Roberts DJ, Bobrovitz N, Zygun DA, Ball CG, Kirkpatrick AW, Faris PD, Parry N, Nicol AJ, Navsaria PH, Moore EE, Leppäniemi AK, Inaba K, Fabian TC, D'Amours S, Brohi K, Stelfox HT.

J Trauma Acute Care Surg. 2015 Oct;79(4):568-79. doi: 10.1097/TA.0000000000000821. Review.


Western Trauma Association Critical Decisions in Trauma: Diagnosis and management of duodenal injuries

Malhotra A, Biffl WL, Moore EE, Schreiber M, Albrecht RA, Cohen M, Croce M, Karmy-Jones R, Namias N, Rowell S, Shatz DV, Brasel KJ.

J Trauma Acute Care Surg. 2015 Dec;79(6):1096-101. doi: 10.1097/TA.0000000000000870. No abstract available.


Western Trauma Association Critical Decisions in Trauma: Management of abdominal vascular trauma

Feliciano DV, Moore EE, Biffl WL.

J Trauma Acute Care Surg. 2015 Dec;79(6):1079-88. doi: 10.1097/TA.0000000000000869. No abstract available.


Shock-induced systemic hyperfibrinolysis is attenuated by plasma-first resuscitation

Moore HB, Moore EE, Morton AP, Gonzalez E, Fragoso M, Chapman MP, Dzieciatkowska M, Hansen KC, Banerjee A, Sauaia A, Silliman CC.

J Trauma Acute Care Surg. 2015 Dec;79(6):897-903; discussion 903-4. doi: 10.1097/TA.0000000000000792.


Combat: Initial Experience with a Randomized Clinical Trial of Plasma-Based Resuscitation in the Field for Traumatic Hemorrhagic Shock

Chapman MP, Moore EE, Chin TL, Ghasabyan A, Chandler J, Stringham J, Gonzalez E, Moore HB, Banerjee A, Silliman CC, Sauaia A.

Shock. 2015 Aug;44 Suppl 1:63-70. doi: 10.1097/SHK.0000000000000376.



Yi J, Slaughter A, Kotter CV, Moore EE, Hauser CJ, Itagaki K, Wohlauer M, Frank DN, Silliman C, Banerjee A, Peltz E.

Shock. 2015 Oct;44(4):336-40. doi: 10.1097/SHK.0000000000000431.


Is Field Resuscitation by Nonsurgeons Equivalent to In-hospital Resuscitation by Trauma Surgeons?

Moore EE, Moore HB.

Ann Surg. 2015 Jul;262(1):e29. doi: 10.1097/SLA.0000000000000618. No abstract available.


Early hemorrhage triggers metabolic responses that build up during prolonged shock

D'Alessandro A, Moore HB, Moore EE, Wither M, Nemkov T, Gonzalez E, Slaughter A, Fragoso M, Hansen KC, Silliman CC, Banerjee A.

Am J Physiol Regul Integr Comp Physiol. 2015 Jun 15;308(12):R1034-44. doi: 10.1152/ajpregu.00030.2015. Epub 2015 Apr 15.


Liver trauma: WSES position paper

Coccolini F, Montori G, Catena F, Di Saverio S, Biffl W, Moore EE, Peitzman AB, Rizoli S, Tugnoli G, Sartelli M, Manfredi R, Ansaloni L.

World J Emerg Surg. 2015 Aug 25;10:39. doi: 10.1186/s13017-015-0030-9. eCollection 2015.


The role of the open abdomen procedure in managing severe abdominal sepsis: WSES position paper

Sartelli M, Abu-Zidan FM, Ansaloni L, Bala M, Beltrán MA, Biffl WL, Catena F, Chiara O, Coccolini F, Coimbra R, Demetrashvili Z, Demetriades D, Diaz JJ, Di Saverio S, Fraga GP, Ghnnam W, Griffiths EA, Gupta S, Hecker A, Karamarkovic A, Kong VY, Kafka-Ritsch R, Kluger Y, Latifi R, Leppaniemi A, Lee JG, McFarlane M, Marwah S, Moore FA, Ordonez CA, Pereira GA, Plaudis H, Shelat VG, Ulrych J, Zachariah SK, Zielinski MD, Garcia MP, Moore EE.

World J Emerg Surg. 2015 Aug 12;10:35. doi: 10.1186/s13017-015-0032-7. eCollection 2015. Review.


Trauma/hemorrhagic shock instigates aberrant metabolic flux through glycolytic pathways, as revealed by preliminary (13)C-glucose labeling metabolomics

D'Alessandro A, Slaughter AL, Peltz ED, Moore EE, Silliman CC, Wither M, Nemkov T, Bacon AW, Fragoso M, Banerjee A, Hansen KC.

J Transl Med. 2015 Aug 5;13:253. doi: 10.1186/s12967-015-0612-z.


Thrombelastographic pattern recognition in renal disease and trauma

Chapman MP, Moore EE, Burneikis D, Moore HB, Gonzalez E, Anderson KC, Ramos CR, Banerjee A.

J Surg Res. 2015 Mar;194(1):1-7. doi: 10.1016/j.jss.2014.12.012. Epub 2014 Dec 10.


Mortality and ratio of blood products used in patients with severe trauma

Moore HB, Moore EE, Gonzalez E.

JAMA. 2015 May 26;313(20):2077. doi: 10.1001/jama.2015.4418. No abstract available.


Duodenum preserving pancreatic head resection (Beger procedure) for pancreatic trauma

Bredbeck BC, Moore EE, Barnett CC Jr.

J Trauma Acute Care Surg. 2015 Mar;78(3):649-51. doi: 10.1097/TA.0000000000000544. No abstract available.


Evolving beyond the vicious triad: Differential mediation of traumatic coagulopathy by injury, shock, and resuscitation.

Kutcher ME, Howard BM, Sperry JL, Hubbard AE, Decker AL, Cuschieri J, Minei JP, Moore EE, Brownstein BH, Maier RV, Cohen MJ.

J Trauma Acute Care Surg. 2015 Mar;78(3):516-23. doi: 10.1097/TA.0000000000000545.


Hemolysis exacerbates hyperfibrinolysis, whereas platelolysis shuts down fibrinolysis: evolving concepts of the spectrum of fibrinolysis in response to severe injury

Moore HB, Moore EE, Gonzalez E, Hansen KC, Dzieciatkowska M, Chapman MP, Sauaia A, West B, Banerjee A, Silliman CC.

Shock. 2015 Jan;43(1):39-46. doi: 10.1097/SHK.0000000000000245.


Predictors of the necessity for early tracheostomy in patients with acute cervical spinal cord injury: a 15-year experience

Jones TS, Burlew CC, Johnson JL, Jones E, Kornblith LZ, Biffl WL, Stovall RT, Pieracci FM, Stahel PF, Moore EE.

Am J Surg. 2015 Feb;209(2):363-8. doi: 10.1016/j.amjsurg.2014.07.016. Epub 2014 Oct 13.