Restless Legs Syndrome
The cause of primary RLS is unknown. RLS may have some genetic components. In some cases, it may be caused by other conditions or certain medications. This is called secondary RLS.
Many people with RLS also have periodic limb movement disorder (PLMD). This is a related motor disorder characterized by:
- Involuntary, repetitive, jerking movements
- Interrupted sleep because of periodic leg movements
Factors that may increase your chance of getting RLS include:
- Family history
- Certain medications, such as antidepressants, antipsychotics, caffeine, theophylline, dopamine antagonists, and sedating antihistamines
Certain chronic diseases may lead to secondary RLS. These include:
- Peripheral neuropathy
- Chronic kidney failure
- Anemia or iron deficiency
- Chronic obstructive pulmonary disease (COPD)
Symptoms may include:
- Feelings of tingling, creeping, pulling, prickling, pins and needles, or pain in the legs during periods of rest or inactivity—may also occur in the arms
- Symptoms typically get worse at night
- A strong urge to relieve uncomfortable sensations with movement
- Restlessness, including floor pacing, tossing and turning in bed, and rubbing the legs
- Difficulty falling asleep and staying asleep
Symptoms may begin at any age, but they are most common in people older than 60 years old. Symptoms usually increase in the evening and during times of rest, relaxation, or inactivity. For this reason, people with RLS generally have insomnia, which may be severe.
The doctor will ask about your symptoms and medical history. A physical and neurological exam will be done. The diagnosis is based mainly on your symptoms. There is no specific test for RLS.
Tests to check for conditions that may trigger RLS include:
- Blood tests
- Monitoring of leg activity during sleep
- Study of leg muscles, such as electromyography (EMG) and nerve conduction studies
|Nerves of the Leg|
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There is no cure for RLS. Treatments are aimed at relieving or reducing symptoms.
Treatment for Mild Cases of RLS
- Massage your legs.
- Use a heating pad or ice pack.
- Take a hot bath.
- Avoid using tobacco, alcohol, or caffeine.
- Follow a sleep routine.
- Begin a safe exercise program with the advice of your doctor.
- Avoid the use of medications that may worsen RLS.
Treatment for Conditions That May Trigger RLS
Effective treatment of conditions that may trigger RLS can ease or resolve your symptoms:
- Kidney failure
Treatment for More Severe Cases of RLS
Dopamine agonists are the only drugs that are FDA approved to treat restless leg syndrome. They are often considered the most effective type of medication for this condition.
Other medications may be used to help control symptoms of restless leg syndrome. Some medication options include clonidine, anticonvulsants, and opioids. Your doctor will select the medication based on your symptoms and medical history.
This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.
Edits to original content made by Denver Health.
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National Sleep Foundation http://www.sleepfoundation.org
Willis-Ekbom Disease Foundation http://www.rls.org
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