Research and Evaluation

Continuum of Opioid Addiction Care in Denver Health 2017

In September 2019, Denver Health published a novel approach to evaluating opioid addiction care based on the HIV cascade of care. The Center for Addiction Medicine is revising the methods and utilizing an updated continuum of opioid addiction care to evaluate our hub-and-spoke model of care.

Read more about the 2020 - 2021 Opioid Continuum of Care at Denver Health here.


Substance-Related Peer-Reviewed Publications

The goal of the Center for Addiction Medicine’s Knowledge Management Workgroup is to enhance information systems to systematically improve processes, generate new knowledge, and drive organizational outcomes. A total of 13 Denver Health substance-related manuscripts or chapters were published in 2022.


  • Binswanger, I. A., Rinehart, D., Mueller, S. R., Narwaney, K. J., Stowell, M., Wagner, N., Xu, S., Hanratty, R., Blum, J., McVaney, K., & Glanz, J. M. (2022). Naloxone Co-Dispensing with Opioids: A Cluster Randomized Pragmatic Trial. Journal of general internal medicine, 10.1007/s11606-021-07356-6
  • Li, X., Sullivan, P., Broz, D., Handanagic, S., & NHBS Study Group (2022). Association Between Dual Partnership and Sexual and Injecting Behaviors Among Persons Who Inject Drugs in 23 US Cities, 2018. Archives of sexual behavior, 51(5), 2667–2678.
  • Terasaki D. (2022). Cardiovascular medications on discharge for patients with chest pain and concurrent cocaine use. The American journal of emergency medicine, S0735-6757(22)00146-2.
  • Thurstone, C., Loh, R., Piatz, C., & Simpson, S. A. (2022). Adolescent Substance Use Disorder Diagnosis Correlates with Hospitalization After an Emergency Department Visit. Pediatric emergency care, 10.1097/PEC.0000000000002838.
  • Binswanger IA, Shetterly SM, Xu S, Narwaney KJ, McClure DL, Rinehart DJ, Nguyen AP, Glanz JM. Opioid Dose Trajectories and Associations With Mortality, Opioid Use Disorder, Continued Opioid Therapy, and Health Plan Disenrollment. JAMA Netw Open. 2022 Oct 3;5(10):e2234671.
  • Stowell, M. A., Thomas-Gale, T., Jones, H. E., Binswanger, I., & Rinehart, D. J. (2022). Perspectives among women receiving medications for opioid use disorder: Implications for development of a peer navigation intervention to improve access to family planning services. Substance abuse, 43(1), 722–732.
  • Choo EK, Nishijima D, Trent S, Eichelberger A, Ye Y, Audett A, Brasel K, Kazmierczak S, Cherpitel CJ. Cannabis presentations to the emergency department after MVC in the era of legalization for recreational use. J Safety Res. 2022 Feb;80:341-348.
  • Fischer LJ, Severtson SG, Gurrola MC, Iwanicki JL, Green JL, Dart RC. Changes in Hydrocodone Misuse Exposures Reported to U.S. Poison Centers Following Rescheduling in 2014. Subst Use Misuse. 2022;57(7):1097-1103.
  • Brooks KM, Castillo-Mancilla JR, Morrow M, Mawhinney S, Rowan SE, Wyles D, Blum J, Huntley R, Salah L, Tehrani A, Jimmerson LC, Roon L, Bushman LR, Anderson PL, Kiser JJ. Predictors of 007 triphosphate concentrations in dried blood spots in persons with hepatitis C and active drug or alcohol use. J Antimicrob Chemother. 2022 Apr 27;77(5):1396-1403.
  • Black JC, Amioka E, Iwanicki JL, Dart RC, Monte AA. Evaluation of Cannabis Use Among US Adults During the COVID-19 Pandemic Within Different Legal Frameworks. JAMA Netw Open. 2022 Nov 1;5(11):e2240526.
  • Choo E, Trent SA, Nishijima DK, Audett A, Hendrickson RG, Eichelberger A, Brasel KJ, Ye Y, Cherpitel CJ. Increased identification of cannabis use among drivers involved in motor vehicle collisions using an expanded cannabis inventory. Acad Emerg Med. 2022 Nov;29(11):1301-1305.
  • Terasaki D, Loh R, Cornell A, Taub J, Thurstone C. Single-dose intravenous ketamine or intramuscular naltrexone for highutilization inpatients with alcohol use disorder: pilot trial feasibility and readmission rates. Addict Sci Clin Pract. 2022 Nov 22;17(1):64.
  • Bradley H, Austin C, Allen ST, Asher A, Bartholomew TS, Board A, Borquez A, Buchacz K, Carter A, Cooper HLF, Feinberg J,Furukawa N, Genberg B, Gorbach PM, Hagan H, Huriaux E, Hurley H, Luisi N, Martin NK, Rosenberg ES, Strathdee SA, Jarlais DCD. A stakeholder-driven framework for measuring potential change in the health risks of people who inject drugs (PWID) during the COVID-19 pandemic. Int J Drug Policy. 2022 Dec;110:103889.


  • Arifkhanova, A., McCormick Kraus, E., Al-Tayyib, A., Taub, J., Encinias, A., McEwen, D., Davidson, A., & Shlay, J. C. (2021). Estimating costs of hospitalizations associated with opioid use disorder or opioid misuse at a large, urban safety-net hospital-Denver, Colorado, 2017. Drug and alcohol dependence, 218, 108306.
  • Calcaterra, S. L., Butler, M., Olson, K., & Blum, J. (2021). The Impact of a PDMP-EHR Data Integration Combined With Clinical Decision Support on Opioid and Benzodiazepine Prescribing Across Clinicians in a Metropolitan Area. Journal of addiction medicine, 10.1097/ADM.0000000000000905. Advance online publication.
  • Calcaterra, S. L., Lou, Y., Everhart, R. M., Fish, L. E., & Hanratty, R. (2021). Association Between In-Clinic Opioid Administration and Discharge Opioid Prescription in Urgent Care: a Retrospective Cohort Study. Journal of general internal medicine, 36(1), 43–50.
  • Kilwein, T. M., Brown, S., Gaffaney, M., & Farrar, J. (2021). Bridging the Gap: Can Group Interventions Assist Addiction Consult Services in Providing Integrated, Comprehensive Healthcare for Patients Hospitalized for Opioid-Related Infections?. Journal of clinical psychology in medical settings, 28(2), 262–266.
  • Kinghorn, W. A., & Nussbaum, A. M. (2021). Prescribing together: A relational guide to psychopharmacology. American Psychiatric Association Publishing.
  • Mueller, S. R., Glanz, J. M., Nguyen, A. P., Stowell, M., Koester, S., Rinehart, D. J., & Binswanger, I. A. (2021). Restrictive opioid prescribing policies and evolving risk environments: A qualitative study of the perspectives of patients who experienced an accidental opioid overdose. The International journal on drug policy, 92, 103077.
  • Rinehart, D. J., Stowell, M., Collings, A., Durfee, M. J., Thomas-Gale, T., Jones, H. E., & Binswanger, I. (2021). Increasing access to family planning services among women receiving medications for opioid use disorder: A pilot randomized trial examining a peer-led navigation intervention. Journal of substance abuse treatment, 126, 108318.
  • Schimmel, J., Amioka, E., Rockhill, K., Haynes, C. M., Black, J. C., Dart, R. C., & Iwanicki, J. L. (2021). Prevalence and description of kratom (Mitragyna speciosa) use in the United States: a cross-sectional study. Addiction (Abingdon, England), 116(1), 176–181.
  • Simpson, S. A., Hordes, M., Blum, J., Rinehart, D., & Al-Tayyib, A. (2021). Barriers to Engagement in Opioid Use Disorder Treatment After Buprenorphine Induction. Journal of addiction medicine, 10.1097/ADM.0000000000000943. Advance online publication.
  • Simpson, S., Shy, B., & Loh, R. (2021). More than suicide: mortality after emergency psychiatric care and implications for practice. Journal of the academy of consultation-liaison psychiatry.
  • Simpson, S., & Taub, J. (2021). Chapter 6: Co-occurring Substance-Use Disorder in the Emergency Department. In L. Zun, K. Nordstrom, & M. Wilson (Eds.), Behavioral Emergencies for Healthcare Providers (2nd ed., pp. 77–88). Springer International Publishing.
  • Toseef, M. U., Armistead, I., Bacon, E., Hawkins, E., Bender, B., Podewils, L. J., & Hurley, H. (2021). Missed appointments during COVID-19: The impact of telehealth for persons experiencing homelessness with substance use disorders. Asian journal of psychiatry, 69, 102987. Advance online publication.