Prescription Drug Addiction



Addiction is marked by an out-of-control need and craving that affects relationships and social obligations, such as work and school. Prescription medications are drugs given to treat a certain condition. Prescription drug addiction is the compulsive seeking and overuse of prescription medications despite harmful consequences. Some medications have a higher risk of addiction. Even with proper use they are associated with alterations in the pathways in the brain. These pathways influence the senses of reward and well-being which can influence addiction.

Medication abuse is inappropriate use of medication. It may include taking higher doses than recommended, snorting pills, mixing with other drugs and alcohol, or using medication for the wrong reasons (such as using pain medication for sleep). Medication (drug) abuse may only develop because of addiction or the addiction may develop after abuse of a medication.

There are certain prescription drugs that are commonly abused because they are more likely to cause addiction. These drugs include:

  • Opioids—used to treat pain, medication examples include:
    • Morphine
    • Codeine
    • Oxycodone
  • Central nervous system depressants—used to treat anxiety and sleep disorders, medication examples include:
    • Barbiturates
    • Benzodiazepines
  • Stimulants—used to treat narcolepsy and attention deficit hyperactivity disorder, medication examples include:
    • Dextroamphetamine
    • Methylphenidate


The reasons people become addicted to prescription drugs are largely unknown. It is most likely due to a combination of factors. The following may play a role in prescription medication addiction:

  • Genetic factors
  • Altered pathways in brain caused by addicting medications
Brain Pathways
Brain nerve pathways
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Risk Factors

Prescription drug addiction is more common in men and people under 30 years old (risk of addiction decreases as age increases). Risk factors for prescription addiction include:

  • Improper use of medication (abuse)
  • Family history of drug addiction
  • Peer pressure and personality traits
  • Having anxiety, depression, loneliness, and a history of alcohol use disorder

Physical dependence may contribute to the development and continuance of addiction. Physical dependence is when your body needs a drug to function normally. Withdrawal symptoms when the medication is stopped or reduced can be a sign of physical dependence. It can make cessation of drug use difficult. Physical dependence may occur with abuse or with long-term proper use of medications.



The symptoms below are associated with prescription drug addiction. If you experience any one of them, see your doctor.

  • Rapid increase in the amount of medication needed
  • Moving from one doctor to another for additional prescriptions
  • Craving the medication
  • Inability to stop or limit medication use
  • Withdrawal symptoms (can be intense and include nausea, vomiting, and sweating)
  • Using significant effort to acquire the medication
  • Medication use that interferes with activities
  • Compulsive use of the medication, despite adverse effects

Let your doctor know if you are having symptoms of physical dependence.


Addiction can be difficult to diagnose. Prescription medication addiction can start with someone who needs frequent medications for a long-term condition like chronic pain. This can make it difficult to distinguish the difference between addiction and medical need.

Your doctor will ask about your symptoms and medical history. A physical exam may be done. Your doctor will ask specific questions about your prescription medication use and may review your refill history.



Talk with your doctor about the best treatment plan for you. Addictions can be treated effectively through detoxification and counseling. Treatment will depend on the type of drug you use and your specific needs.

Treatment options include the following:


This involves managing the symptoms of withdrawal while the medication leaves your system. Some symptoms of withdrawal can be life-threatening. Your medical team will slowly taper you off the drug and monitor your body's reactions.

Other medications may be used to counteract the effects of addiction and withdrawal symptoms. This should be done under the supervision of a doctor in a hospital or other outpatient setting to ensure your safety and effective detoxification.

It is important to follow up with other therapies to avoid relapse.

Behavioral Therapies

Behavioral therapies can help. This therapy will help you learn to function without the medication, handle cravings, and avoid situations in which relapse is likely. Behavioral therapy may include individual, group, or family counseling.


Certain medications can be used to treat opiate dependence that may be present with addiction. They may be used during detoxification to reduce withdrawal symptoms. They may also be continued through maintenance to decrease craving and reduce the risk of relapse. They are given as a part of an overall treatment approach including counseling. Common medication options include:

  • Methadone
  • Buprenorphine
  • Naltrexone

The choice of medication will depend on the drugs involved in the addiction, your medical history, and your recovery commitment.

Other medications may be needed to treat underlying issues, such as depression or anxiety. These medications may help you on your way to a full and productive life as well as prevent relapse.


To help reduce your chance of developing a prescription drug addiction:

  • Carefully follow directions.
  • Be aware of potential interactions with other drugs.
  • Talk with your doctor before changing the dose.
  • Never use another person's prescription.
  • Tell your doctor all the medications you are taking. This includes over-the-counter medications and dietary and herbal supplements.

This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.

Edits to original content made by Denver Health.


Narcotics Anonymous 

National Institute on Drug Abuse 


Canadian Centre on Substance Abuse 

Drug Rehab Services 


Addiction. National Coalition Against Prescription Drug Abuse website. Available at: Accessed May 15, 2012.

Opioid abuse or dependence. EBSCO DynaMed Plus website. Available at: . Updated September 8, 2016. Accessed September 27, 2016.

Prescription drugs & cold medicines. National Institute on Drug Abuse website. Available at: Accessed May 15, 2012.

2/4/2010 DynaMed Plus Systematic Literature Surveillance : Schinke SP, Fang L, et al. Computer-delivered, parent-involvement intervention to prevent substance use among adolescent girls. Prev Med. 2009;49(5);429-435.