Nerve damage may be from:
- Trauma from nerve compression or inflammation
- Some medicines, such as chemotherapy treatments for cancer
- Lacking some vitamins
- Exposure to toxins and heavy metals, such as lead, mercury, or pesticides
- Exposure to cold or radiation
- Alcohol use disorder
Health problems that can damage these nerves are:
- Infections, such as Lyme disease and tuberculosis
- Kidney failure
- Autoimmune disorders, such as rheumatoid arthritis
- Acute or chronic demyelinating polyneuropathy
- Paraneoplastic syndromes
- Hereditary syndromes, such as Charcot Marie Tooth disease
Damage may cause sensory and motor problems in the arms, hands, legs, and feet. Other parts of the body may also have problems. It depends on which nerves are affected.
Problems may be mild and then get worse over time. They may be worse at night. A person may have:
- Numbness or lack of feeling
- Pain, often a burning or sharp, or cutting feeling
- Sensitivity when touched
- Muscle spasms
- Muscle weakness
- Problems walking
- Loss of coordination or balance
The doctor will ask about symptoms and past health. A physical exam will be done. Blood and urine tests will be done to rule out other problems or possible causes.
Your nerves will be tested. This can be done with:
- Electromyography (EMG)
- Nerve conduction studies (NCS)
Other tests to look for possible causes may be:
- CT scan
- MRI scan
- Lumbar puncture to test the fluid around your spine
- Nerve or muscle biopsy
Treatment depends on what is causing the neuropathy. This can ease symptoms or make them go away. Other treatment options may be:
Exercises may be given to help with flexibility. It may help make walking easier.
Pain medicine is often used. Botulinum toxin A injections may also ease pain.
Medicines used to treat depression and prevent seizures can ease some symptoms.
People with severe problems may need:
- IV immunoglobulins to suppress the immune system
- Plasma exchange of the blood to ease swelling and suppress the immune system
This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.
Edits to original content made by Denver Health.
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American Chronic Pain Association http://www.theacpa.org
The Neuropathy Association http://www.neuropathy.org
Canadian Diabetes Association http://www.diabetes.ca
Health Canada https://www.canada.ca
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Peripheral neuropathy fact sheet. National Institute of Neurological Disorders and Stroke website. Available at: https://www.ninds.nih.gov/disorders/patient-caregiver-education/fact-sheets/peripheral-neuropathy-fact-sheet. Accessed October 16, 2020.
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